Loss of TRPM2 function protects against irradiation-induced salivary gland dysfunction
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چکیده
منابع مشابه
Neurturin Gene Therapy Protects Parasympathetic Function to Prevent Irradiation-Induced Murine Salivary Gland Hypofunction
Head and neck cancer patients treated with irradiation often present irreversible salivary gland hypofunction for which no conventional treatment exists. We recently showed that recombinant neurturin, a neurotrophic factor, improves epithelial regeneration of mouse salivary glands in ex vivo culture after irradiation by reducing apoptosis of parasympathetic neurons. Parasympathetic innervation ...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2013
ISSN: 2041-1723
DOI: 10.1038/ncomms2526